Academic Background:
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Ph.D.,
Pharmaceutical Sciences, University of Missouri-Kansas City,
Kansas City, MO, 1995
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Post-bachelor
Fellow, Department of Pathology, Kirksville College of
Osteopathic Medicine, Kirksville, MO, 1986
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B.S., Pharmacy
and Biochemistry, Universidad National Mayor de San Marcos,
Lima, Peru, 1985
Research Interests:
My research
interest is to develop mechanism-based methods for the toxicological
evaluation of nanostructured materials, biomaterials and drugs.
Test development and application involves cell culture technology
for evaluation of cytotoxicity, apoptosis, genotoxicity (mutagenicity,
DNA damage and repair), inflammation, endocrine disrupting activity
and in vitro metabolism. Some in vitro activity using
liposome technology is aimed at developing methods that detect
cytotoxicity at the level of cell membrane damage. Toxicity of
biomaterials is also assessed for the release of toxic leachables,
their metabolism and detoxification. Monomers and resin/composite
leachables and their metabolites are analyzed by HPLC, NMR, and TLC.
Most methodologies support development of mathematical equations
based on quantitative structure activity relationships (QSAR) for
determination of mutagenicity, skin sensitization and cytotoxicity.
Research Grants:
My research interests are supported by NIH grants as ongoing
research collaborations with UMKC Schools of Dentistry and
Chemistry, Midwest Research Institute, and 3M-ESPE dental Product
Division.
Representative Publications:
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Kostoryz
EL,
Q. Zhu, H Zhao, M Miller, JD Eick. ”Assessment of the
Relative Skin Sensitization Potency of Siloranes and bis-GMA
using the Local Lymph Node Assay and QSAR Predicted Potency”
J Biomed Mater Res 2006, (in press). |
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Kostoryz
EL,
Zhu Q, Zhao H, Glaros AG, Eick JD, “Assessment of DNA damage
for silicon-oxirane compounds in cultured mammalian cells,”
Mutat Res 2006 (in press). |
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Brockmann
W.G., Kostoryz EL,
Eick JD, “Correlation of apoptotic potential of simple
oxiranes with cytotoxicity,” Toxicology in Vitro, 20:
729-735,
2006. |
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Eick JD,
Robert E Smith, and Charles S. Pinzino,
Kostoryz EL,
“Stability of silorane dental monomers in aqueous systems,”
Journal of Dentistry 34(6): 405-410, 2006. |
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JD Eick,
RE Smith, CS Pinzino, SP Kotha, EL Kostoryz, and
Cecil C. Chappelow, ”Photopolymerization of Developmental
Monomers for Dental Cationically Initiated Matrix Resins,”
Dental Materials, 2005, 21 (4), pp.384-390. |
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Eick,
JD, Smith, RE, Pinzino, CS, Kotha, SP, Kostoryz, EL,
Chappelow, CC, “Photopolymerization of Developmental
Monomers for Dental Cationically Initiated Matrix Resins,”
Dental Materials, 2004, 22(8), pp. 1-7. |
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Bharat
W, Kostoryz EL, Lee C, “Biocompatibility of
components of a female controlled drug delivery system,” J
Biomed mater Res 71A: 209-216, 2004. |
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Kostoryz
EL, Zhao H, Eick JD, “Differences in DNA repair
influenced by structural differences among oxirane
compounds,” ASM Conference, November 14-20, 2004. |
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E.L.
Kostoryz, L.A. Wetmore, W.G. Brockmann, D.M. Yourtee,
J.D. Eick, “Genotoxicity assessment of oxirane-based dental
monomers in mammalian cells,” J Biomed Mater Res, 68A:
660-667, 2004. |
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Luchtefeld, R, Kostoryz EL, Smith RE,
“Determination of Ginsenosides Rb1, Rc and Re in Different
Dosage Forms of Ginseng by Negative Ion Electrospray LC-MS,”
J Agricultural & Food Chem, 52:4953-49-56, 2004. |
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EL
Kostoryz, RE Smith, AG Glaros, CC Chappelow, JD Eick,
“In vitro mutagenicity and metabolism of the cycloaliphatic
epoxy CyracureTM UVR 6105,” Mutat Res, 563:
35-47, 2004. |
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